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RESULTS Total AA concentrations AA DHA ; in hepatocytes isolated from young and old rats are displayed in Table 1. DHA concentrations, assessed as the difference between AA and total AA measurements, were negligible in both supplemented and control rats data not shown ; . However, a significant 54% decrease in total AA with age was observed P0.0005 ; . A 2 supplementation regimen with R ; -lipoic acid 0.5% w w ; in the diet ; resulted in a highly significant 127 % increase in hepatic AA concentration in cells from old rats P0.0001 ; , completely restoring the levels to those found in cells from untreated young rats. In cells from young animals, a significant 44% increase in AA concentration was also observed with R ; -lipoic acid supplementation P0.05 ; . AA recycling and synthesis as measured by reduction of DHA and biosynthesis from GL were used as parameters of response to an oxidative insult imposed by t-BuOOH. Hepatocytes isolated from young and old rats were incubated with 0, 300, or 500 mM tBuOOH for 1 h at before the experiments. The results of the AA recycling experiments are summarized in Fig. 2. For cells from young rats, there was no significant difference in recycling capacity between cells preincubated with 300 or 500 mM tBuOOH compared to controls, indicating that cells from young animals can adequately respond to the tBuOOH-induced insult at these concentrations. In contrast, cells isolated from old rats lacked the ability.

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In addition to giving us your shipping and billing information, you will also need to answer a short medical questionnaire in order to provide important information about your medical condition. Source: Reuters Writes through with quotes, reaction ; By Maggie Fox, Health and Science Correspondent WASHINGTON, May 23 Reuters ; - AstraZeneca's AZN.L cholesterol-lowering drug Crestor has more than double the side effects of rival statin drugs, including deaths, U.S. researchers reported on Monday. Adverse effects include muscle damage known as myopathy, including a severe form known as rhabdomyolysis; proteinuria or protein in the urine; nephropathy, a reduced ability of the kidneys to filter toxins from the blood; and kidney failure. But the American Heart Association, which published the study in its journal Circulation, said the drug was still generally safe if prescribed properly and urged patients not to panic or stop taking the drug. And AstraZeneca said it strongly disagreed with the study's conclusions. Dr. Richard Karas of the Tuft-New England Medical Center in Boston, who led the study, said his team found a rate of 28 adverse events per million prescriptions of Crestor, known generically as rosuvastatin. That was about 2.2 times more than the adverse events seen with simvastatin, made by Merck and Co. MRK.N under the brand name Zocor and 6.8 times higher than atorvastatin, made by Pfizer Inc. PFE.N under the brand name Lipitor, he said. Karas said there were 6 per million deaths on Crestor as compared to 3 per million for Zocor, 1 per million with Bristol Myers Squibb's BMY.N Pravachol and 2 per million for Lipitor. "It would seem prudent at the current time for healthcare providers to consider other statins as first-line therapy, to initiate therapy in appropriate patients at lower doses, to consider combination LDL-C lowering therapy eg, statin combined with ezetimibe ; , and to vigilantly monitor for adverse events if rosuvastatin is used, " they concluded. REFUSAL TO BAN "We strongly disagree with the conclusions of this study, " the company said in a statement. "The study implies that because post-marketing rates of spontaneous adverse event reports were higher, the risk is also higher. This is factually incorrect, ' it added. " . These reports are just that, reports, not medically confirmed cases." In March, the U.S. Food and Drug Administration denied a petition by the consumer group Public Citizen to ban Crestor, saying it disagreed with arguments that Crestor was more dangerous than other statins. For the study, Karas and colleagues looked at adverse events.
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